MDMA-Assisted Psychotherapy: A Promising Treatment for PTSD

Post Summary

May 6, 2021
MDMA-assisted psychotherapy is demonstrating to be promising for PTSD. Source: Activedia/Pixabay, Creative Commons In recent years, MDMA-assisted psychotherapy has been highlighted as a breakthrough therapy in the…
MDMA-assisted psychotherapy is demonstrating to be promising for PTSD.
Source: Activedia/Pixabay, Creative Commons

In recent years, MDMA-assisted psychotherapy has been highlighted as a breakthrough therapy in the treatment of post-traumatic stress disorder (PTSD) and other mental health disorders. The properties of MDMA that make it helpful in therapy include boosting empathy and compassion, as well as increasing feelings of interpersonal closeness and tolerance of distressing memories.

The Multidisciplinary Association for Psychedelic Studies (MAPS) is a non-profit research and educational organization focused on the medical benefits of psychedelics and marijuana, including MDMA-assisted psychotherapy. Their main project is a $26.9 million plan to make MDMA an approved prescription medicine under the U.S. Food and Drug Administration (FDA) by 2021.

Currently MDMA is only approved for use in research, and there is no approval for use in therapy. The expanded access of the use of MDMA under a treatment protocol will address conditions for patients who do not currently have promising treatment options or for whom conventional psychotherapy or pharmacological treatments have been ineffective. A recent trial with individuals with chronic PTSD who failed to respond to other treatments found that after just two to three sessions of psychotherapy with active doses of MDMA, symptoms were markedly reduced. Twelve months later, most participants no longer met the criteria for PTSD.

The Remedy clinic in Toronto, which has co-facilitated research with MAPS, is actively researching the use of MDMA-assisted cognitive processing therapy for couples where one or both partners have been diagnosed with PTSD. Both clients, regardless of diagnosis, are treated with one 80mg dose of MDMA in the morning and can choose to receive an additional supplemental half-dose an hour and a half into the session. During the session, clients are seated in a reclining chair or futon and spend the day “going inside,” or entering a reflective internal state from which they talk to the therapist and to each other. After staying overnight, clients meet with the therapist for an integration session or a conversation about the therapy.

In an interview with us, Anne Wagner, a psychologist and founder of Remedy, discussed the benefits of using MDMA within the therapy session:

“We see MDMA as being an adjunct to the therapy process that can potentially enhance the effects of the therapy. What MDMA allows the couple to do is create a deep and meaningful bonding experience that allows them to process their feelings about symptoms together… The MDMA experience varied between people but what we have noticed is that people are able to stay with their emotions and not run away with them; trying to avoid emotions is a hallmark of PTSD. Staying with whatever comes up and going into the traumatic memory without wanting to turn away from it is very important because running away from trauma is what keeps people stuck.”

Wagner describes the role of the therapist during a session:

“We are there to help them go through this experience. As therapists, we try to coordinate the interactions between the partners. If one is having an experience, we wait until they are at a point where they are able to receive the other person’s insights or experience by taking notes and relaying them back to the partner.”

There is also the potential for MDMA-assisted psychotherapy to be helpful even with clients who do not have symptoms of PTSD. Wagner explains:

“The couple’s work is very important because we are not only treating clients with PTSD, but we’re also treating the functioning of the relationship. I’m hopeful that this technique will be used for people who don’t have a PTSD diagnosis, but who are struggling with issues in their life outside of a clinical diagnosis. It’s looking at the experience and looking at all the context that was there, and not the story we have woven about it. It’s more about being able to see it with more nuance and complexity that’s really important, and that’s what ultimately helps with acceptance.”


There are some limitations on the use of MDMA in therapy; individuals who are on SSRIs are not treated with MDMA. And according to Wagner, clients should be in good physical health, and any existing conditions should be closely monitored. Substance use disorders, such as alcoholism, or any other drug usage that could result in withdrawal symptoms, psychosis, or mania may disqualify clients as well.

–Eleni Neofytou, contributing writer,
The Trauma and Mental Health Report

–Chief editor: Robert T. Muller,
The Trauma and Mental Health Report

Robert T. Muller